CONTACT US

Our Address

Science Avenue, High-tech Zone, Zhengzhou City, Henan Province, China

  • Quadrupole mass analyzer - Wikipedia

    OverviewPrinciple of operationMultiple quadrupoles, hybrids and variationsApplicationsSee also

    The quadrupole mass analyzer (QMS) is one type of mass analyzer used in mass spectrometry. It is also known as a transmission quadrupole mass spectrometer, quadrupole mass filter, or quadrupole mass spectrometer. As the name implies, it consists of four cylindrical rods, set parallel to each other. In a quadrupole mass spectrometer the quadrupole is the mass analyzer - the component of the instrument responsible for selecting sample ions based on their mass-to-charge ratio(m/z). Ions are separated in a

  • Wikipedia CC-BY-SA 许可下的文字
  • Mass spectrometry - Wikipedia

    A quadrupole mass analyzer acts as a mass-selective filter and is closely related to the quadrupole ion trap, particularly the linear quadrupole ion trap except that it is designed to pass the untrapped ions rather than collect the trapped ones, and is for that reason referred to as a transmission quadrupole. A magnetically enhanced quadrupole ...

  • Quadrupole Mass Analyzer - an overview ScienceDirect Topics

    W. Clarke, in Mass Spectrometry for the Clinical Laboratory, 2017. 1.3.1 Quadrupole Mass Analyzers. A quadrupole mass analyzer consists of a set of four conducting rods arranged in parallel, with a space in the middle; the opposing pairs of rods are electrically connected to each other. This type of mass analyzer separates ions based on the stability of their flight trajectories through an ...

  • Apple of their eye: The world’s first miniature triple ...

    Triple quadrupole mass spectrometers are designed for conducting tandem mass spectrometry (MS) and are particularly effective at determining the concentration of analytes separated by chromatography. They contain three separate quadrupole mass analyzers in series; each quadrupole analyzer consists of four long rods arranged in parallel, leaving ...

  • Quadrupoles - an overview ScienceDirect Topics

    The quadrupole mass filter (Fig. 3) is a widely used mass analyzer that has benefited from 30 years of continual commercial development and refinement.It consists of four accurately aligned parallel metal rods that are arranged symmetrically around a central axis that is the path of ion movement from ion source to ion detector.

  • Quadrupole mass analyzer, principle

    Quadrupole mass analyzer. A quadrupole analyzer consists of four parallel hyperbolic or cylindrical electrodes. The opposite electrodes 2r 0 apart are interconnected and subjected to the same potential (Figure 1). The adjacent electrodes are applied to potentials of values Ф 0 = 2(U – Vcosωt), sum of a direct voltage U and a high frequency alternating current V (ω).

  • Quadrupole - Widener University

    Quadrupole (1). The quadrupole mass spectrometer is the most common mass analyzer. Its compact size, fast scan rate, high transmission efficiency, (2) and modest vacuum requirements are ideal for small inexpensive instruments. Most quadrupole instruments are limited to unit m/z resolution (3) and have a mass range of m/z 1000. Many benchtop instruments have a mass range of m/z 500 but research ...

  • US3936634A - Method and apparatus for improved focusing of ...

    US3936634A US05/531,375 US53137574A US3936634A US 3936634 A US3936634 A US 3936634A US 53137574 A US53137574 A US 53137574A US 3936634 A US3936634 A US 3936634A Authority US United States Prior art keywords potential ions accordance mass filter ground Prior art date 1973-03-30 Legal status (The legal status is an assumption and is not a legal conclusion.

  • 6.3 Quadrupole mass spectrometers (QMS)

    The higher the mass range within which adjacent masses should be differentiated, the stricter will be the requirements relating to the relative accuracy of the mass filter. Summary. A quadrupole mass filter is a dynamic mass filter for positive and negative ions. The mass

  • Quadrupole Time-of-Flight Mass Spectrometry: A Paradigm ...

    Introduction. Q-TOF-MS is an analytical technique that advantageously combines the benefits of two different mass analysers. Utilising the high compound fragmentation efficiency of quadrupole technology in combination with the rapid analysis speed and high mass resolution capability of time-of-flight, a unique ‘hybrid’ analyser was introduced. 1 Originally developed in the early 1980s, the ...

  • Quadrupole mass spectrometer instrument Britannica

    Other articles where Quadrupole mass spectrometer is discussed: mass spectrometry: Ion-velocity spectrometers: described the development of a quadrupole mass spectrometer. The application of superimposed radio frequency and constant potentials between four parallel rods can be shown to act as a mass separator in which only ions within a particular mass range will perform oscillations of ...

  • Transmission through the quadrupole mass spectrometer

    1. This diagram shows the geometry of the ideal quadrupole mass filter. The aperture radius and the aperture angle are measured in the x–y plane. The z axis is the major axis of the mass lens. 2277 Voo et al.: Transmission through the quadrupole mass 2277 JVST A - Vacuum, Surfaces, and Films

  • QP2020 NX single quadrupole GC/MS SQ-GCMS GC-MS

    This is effective for scan data sensitivity improvements and favorable mass spectrum acquisition, particularly in high-speed analysis with Fast-GC/MS, simultaneous Scan/SIM, FASST analysis, and applications using Comprehensive GC/MS (GC x GC/MS). The precision-designed quadrupole mass filter is able to obtain accurate mass assignments across ...

  • US3936634A - Method and apparatus for improved focusing of ...

    US3936634A US05/531,375 US53137574A US3936634A US 3936634 A US3936634 A US 3936634A US 53137574 A US53137574 A US 53137574A US 3936634 A US3936634 A US 3936634A Authority US United States Prior art keywords potential ions accordance mass filter ground Prior art date 1973-03-30 Legal status (The legal status is an assumption and is not a legal conclusion.

  • High Sensitivity Quantitation of Nitrosamine Genotoxic ...

    Xevo TQ-XS Triple Quadrupole Mass Spectrometry Nitrosamines Abstract / Summary. Use of the reversed-phase HSS T3 Column provided excellent retentivity for nitrosamine impurities, particularly the most polar nitrosamine, NDMA, while also providing separation from ranitidine API. Detection using a tandem quadrupole MS system with MRM analysis ...

  • Mass Spectrometry: Quadrupole Mass Filter Mass ...

    Quadrupole mass filter Successful path Detector X Y Fig. 2: Schematic of a quadrupole mass filter. A quadrupole mass spectrometer consists of an ionizer (bombardment by electrons from a hot filament), an ion accelerator, and a mass filter consisting of four parallel metal rods arranged as in the figure above.

  • Linear quadrupoles in mass spectrometry - Douglas - 2009 ...

    John R. Gibson, Kenneth G. Evans, Sarfaraz U. Syed, Simon Maher, Stephen Taylor, A Method of Computing Accurate 3D Fields of a Quadrupole Mass Filter and Their Use for Prediction of Filter Behavior, Journal of The American Society for Mass Spectrometry, 10.1007/s13361-012-0426-7, 23, 9, (1593-1601), (2012).

  • Inductively Coupled Plasma Mass Spectrometry: Introduction ...

    Quadrupole. As is the case with all mass analysers, a quadrupole is essentially a mass filter, separating ions based on their m/z ratio (defined as the mass of an ion divided by its charge). A quadrupole consists of four parallel hyperbolic or cylindrical metallic rods (normally 15–20 cm long) positioned in a square array.

  • Workhorses of the Chromatography Lab: Quadrupoles and Ion ...

    Today, quadrupole mass spectrometers are the undisputed workhorses of every analytical lab, whether their studies involve trace analysis, quality control, quantitative or qualitative, organic or ... rods with particularly high surface quality and length, as shown in Figure 4, provide the ideal quadrupole Figure 2. Quadrupole mass filters with ...

  • 6.3 Quadrupole mass spectrometers (QMS)

    At extremely low pressures, particularly in the UHV range, open ion sources are used which have a particularly small surface area and therefore low outgassing rates (grid ion source). Due to the low gas densities, secondary electron multipliers (SEM) that are arranged perpendicular to the axis of the quadrupole must be used as detectors.

  • Smart Note: Triple Quadrupole ICP-MS or Single Quadrupole ...

    Triple Quadrupole ICP-MS or Single Quadrupole ICP-MS? Which Instrument is Right for Me? SmartNotes iCAP TQ ICP-MS The IUPAC definition of a triple quadrupole mass spectrometer is a ‘tandem mass spectrometer comprising two transmission quadrupole mass spectrometers in series, with a (non-selecting) RF-only quadrupole (or other multipole) between them to act as a collision cell’1.

  • US3457404A - Quadrupole mass analyzer - Google Patents

    US3457404A US3457404DA US3457404A US 3457404 A US3457404 A US 3457404A US 3457404D A US3457404D A US 3457404DA US 3457404 A US3457404 A US 3457404A Authority US United States Prior art keywords electrodes ion ions quadrupole analyzer Prior art date 1965-09-13 Legal status (The legal status is an assumption and is not a legal conclusion.

  • Mass Spectrometry Facility Quadrupole

    The quadrupole mass analyser was developed in parallel with the quadrupole ion trap by the third Nobel prize winning mass spectrometry pioneer, Wolfgang Paul [1,2]. A quadrupole mass analyser consists of four parallel rods (see figure) that have fixed DC and alternating RF potentials applied to them.

  • Workhorses of the Chromatography Lab: Quadrupoles and Ion ...

    Today, quadrupole mass spectrometers are the undisputed workhorses of every analytical lab, whether their studies involve trace analysis, quality control, quantitative or qualitative, organic or ... rods with particularly high surface quality and length, as shown in Figure 4, provide the ideal quadrupole Figure 2. Quadrupole mass filters with ...

  • Quadrupole mass spectrometer instrument Britannica

    Other articles where Quadrupole mass spectrometer is discussed: mass spectrometry: Ion-velocity spectrometers: described the development of a quadrupole mass spectrometer. The application of superimposed radio frequency and constant potentials between four parallel rods can be shown to act as a mass separator in which only ions within a particular mass range will perform oscillations of ...

  • Triple Quadrupole Mass Spectrometer (QqQ MS) Labcompare

    A triple-quadrupole mass spectrometer, also known as QqQ, is a tandem MS method in which the first and third quadrupoles act as mass filters and the second causes fragmentation of the analyte through interaction with a collision gas—it is a radiofrequency-only quadrupole, and can be used in

  • US3457404A - Quadrupole mass analyzer - Google Patents

    US3457404A US3457404DA US3457404A US 3457404 A US3457404 A US 3457404A US 3457404D A US3457404D A US 3457404DA US 3457404 A US3457404 A US 3457404A Authority US United States Prior art keywords electrodes ion ions quadrupole analyzer Prior art date 1965-09-13 Legal status (The legal status is an assumption and is not a legal conclusion.

  • Linear quadrupoles in mass spectrometry - Douglas - 2009 ...

    John R. Gibson, Kenneth G. Evans, Sarfaraz U. Syed, Simon Maher, Stephen Taylor, A Method of Computing Accurate 3D Fields of a Quadrupole Mass Filter and Their Use for Prediction of Filter Behavior, Journal of The American Society for Mass Spectrometry, 10.1007/s13361-012-0426-7, 23, 9, (1593-1601), (2012).

  • Mass Spectrometry: A Technology and Market Overview

    Aug 27, 2018  While biomolecular analysis was one of the most commonly used applications of mass spectrometry, Quadrupole LC/MS applied markets are predicted to be the largest driver of growth, particularly in Asia.Quadrupole LC/MS applied markets are comprised of food, environmental labs, and clinical research labs. This shift is primarily due to the increase in regulations both domestic and

  • A novel tandem quadrupole mass analyzer Journal of the ...

    A new “tandem mass analyzer” is described. Two quadrupole mass filters are operated in series. Each is operated at low resolution and a small mass offset is introduced between the two quadrupoles so that the pair operate together to give higher resolution. The resolution of the tandem analyzer can be changed by changing the mass offset. The transmission is highest when the quadrupoles are ...

  • Mass spectrometry - LinkedIn SlideShare

    Dec 22, 2014  Quadrupole The quadrupole mass analyzer is one type of mass analyzer used in mass spectrometry. As the name implies, it consists of four cylindrical rods, set parallel to each other. In a quadrupole mass spectrometer the quadrupole is the component of the instrument responsible for filtering sample ions, based on their mass-to-charge ratio (m/z).

  • Smart Note: Triple Quadrupole ICP-MS or Single Quadrupole ...

    Triple Quadrupole ICP-MS or Single Quadrupole ICP-MS? Which Instrument is Right for Me? SmartNotes iCAP TQ ICP-MS The IUPAC definition of a triple quadrupole mass spectrometer is a ‘tandem mass spectrometer comprising two transmission quadrupole mass spectrometers in series, with a (non-selecting) RF-only quadrupole (or other multipole) between them to act as a collision cell’1.

  • Mass Accuracy and Resolution : Waters

    Mass Accuracy and Resolution. Increased, measured mass accuracy and resolution is now a dominant tool for structural characterization in various applications beyond early drug discovery. With their broad reach of specificity and utility, quadrupole time-of-flight (QTOF) instruments, offered by a number of manufacturers today, are replacing other LCMS technologies.

  • Quadrupole Mass Spectrometer - COMSOL Multiphysics®

    The quadrupole mass filter has been well studied over the years, Ref. 1 and the physics and optimal design are well understood. In a real quadrupole mass spectrometer, fringe fields exist at both the entrance and exit of the mass filter. These fringe fields can play an important role in determining the transmission probability of a specific ion ...

  • Understanding Quadrupole Theory

    May 20, 2014  A quadrupole mass filter is composed of four mutually parallel, highly precise, electrically-isolated electrodes. The orientation of the electrodes is such that there is a hyperbolic (quadrupolar) electric field between them. The common quadrupole fabrication technique involves positioning the four round poles in such a fashion that the centers ...

  • Principles of Quadrupole and Ion Trap Mass Analyzers

    The Mass Peak in the Quadrupole Mass Spectrum A common phrase in texts on MS says, “Examine the peaks in the mass spectrum.” Why is the mass peak a peak? Why not a a single line (it’s a single mass, after all)? There are a few reasons, but the most fundamental is related to the nature of the quadrupole ion filter itself.

  • ICP-MS? Quadrupole ICP-MS Lab

    Jul 06, 2020  The quadrupole mass filtering process is extremely fast. For example, the quadrupole can scan over the 1-200 amu range in ≤ 20ms, or switch repeatedly from peak to peak in jumps of 1.8-25 µs (Houk 1986, Steel and Henchman 1998).

  • A novel tandem quadrupole mass analyzer Journal of the ...

    A new “tandem mass analyzer” is described. Two quadrupole mass filters are operated in series. Each is operated at low resolution and a small mass offset is introduced between the two quadrupoles so that the pair operate together to give higher resolution. The resolution of the tandem analyzer can be changed by changing the mass offset. The transmission is highest when the quadrupoles are ...

  • 13 questions with answers in QUADRUPOLE MASS

    Jan 01, 2020  Quadrupole Mass Spectrometry - Science topic Explore the latest questions and answers in Quadrupole Mass Spectrometry, and find Quadrupole Mass Spectrometry experts. Follow topic

  • Development of Quadrupole Mass Spectrometers Using

    Development of Quadrupole Mass Spectrometers Using Prototyping Technology ... number of mass spectrometry applications, particularly for field applications such as instant medical diagnosis, water and environmental analysis, and detection of oil, natural gas, and explosives [1].

  • Quadrupole Ion Trap Mass Spectrometry, 2nd Edition ...

    Quadrupole Ion Trap Mass Spectrometry, 2nd Edition Raymond E. March , John F. Todd A definitive reference, completely updatedPublished in 1989, the First Edition of this book, originally entitled Quadrupole Storage Mass Spectrometry, quickly became the definitive reference in analytical laboratories worldwide.

  • ATMOSPHERIC PRESSURE QUADRUPOLE MASS SPECTROMETRY

    These studies have as a primary goal the development of a true mass spectrometer operating under atomospheric pressure conditions. Removing the requirement for vacuum operating biomedical analysis; with both identify and quantification problems. We intend to demonstrate the ability of a linear quadrupole device to act as a true mass filter.

  • MS Section 5.5.2

    Quadrupole mass filters have become the most common type of MS used today due to their relatively small size, light weight, low cost, and rapid scan times (less than 100 ms). This type of mass filter is most commonly used in GC applications and to some extent in LC systems because they are able to operate at a relatively high pressure (5 x 10 ...

  • Real-time quadrupole mass spectrometer analysis of gas in ...

    and the quadrupole mass spectrometer (QMS) gas analysis employed at the Frio field site. For a detailed description of the Frio Pilot carbon sequestration experiment and tra-cer analysis, the reader is referred to Freifeld et al. (2005). Geofluids (2006) 6, 217–224 doi: 10.1111/j.1468-8115.2006.00138.x 2006 The Authors

  • The quadruple mass filter: Basic operating concepts

    quadrupole mass analyzer with an inductively coupled plas- ma ion source (ICP-MS) (4, 5), and the successive use of quadrupole mass analyzers as a method of performing mass spectrometry-mass spectrometry (MS-MS) experiments (6-8). A third useful feature of the quadrupole mass analyzer is the mechanical simplicity of the instrument. Unlike many

  • Global study of quadrupole correlation effects - NASA/ADS

    (v) Inclusion of the quadrupole correlation energy improves the description of mass systematics, particularly around shell closures, and of differential quantities, namely two-nucleon separation energies and two-nucleon gaps. The correlation energy provides an explanation of “mutually enhanced magicity.”

  • 1 Mass Spectrometry of Amino Acids and Proteins

    Quadrupole mass filters [13], as the name implies, are made from four parallel ... particularly useful in the quantitation of known molecules. There are other less frequently used tandem MS scans (e.g., neutral loss scans) and it should be noted 1.1 Introduction j 5.

  • using quadrupole/time-of-flight mass spectrometry on the ...

    particularly useful to follow a fragmentation cascade. Recently, the combination of the quadrupole mass analyser with a time-of-flight mass analyser (QqTOF) has been described [8,9]. QqTOF is particularly powerful to obtain product ion spectra at medium resolution with the possibil-ity of accurate mass measurement of the fragments. This

  • Thermo Scientific TSQ Endura Triple Quadrupole Mass ...

    The Thermo Scientific Endura Triple Quadrupole Mass Spectrometer meets these needs with unsurpassed value. It delivers best-in-class sensitivity run after run and day after day regardless of sample type or matrix, and does so with an ease-of-use that takes the worry out of method development and operation. **Left side panel is missing.

  • Triple Quadrupole Liquid Chromatograph Mass Spectrometer ...

    LCMS-8040 Triple Quadrupole Liquid Chromatograph Mass Spectrometer (LC-MS/MS) ... software package that enables faster quantitative analysis and more effective reviewing of multi-analyte panels particularly for food, cannabis, clinical research, and forensics markets .

  • Electrospray mass spectrometry of human hair wax esters

    The wax ester mixture was analyzed by ESI and tandem mass spectrometry using multiple reaction monitoring and neutral loss scanning. The neutral loss experiment [loss of NH3 and CH2=CH-(CH2)nCH3] was particularly effective at rapidly surveying the complex biological mixture, identifying>160 different wax esters that range from 24 to 42 total ...